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x = (-3 + 5)/2 = 1; y = (4 - 2)/2 = 1
La pendiente definida por los puntos es: m = (-2 -4)/(5+3) = - 3/4
La pendiente de la recta normal es m' = -1/m = 4/3
La recta pedida es y - 1 = 4/3 (x - 1)
O bien y = 4/3 x - 1/3
Adjunto gráfico.
Saludos Herminio