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Primero ordenamos
(x+2) (x-2) (x^2+2) + 4
Multiplicamos (x+2) (x-2)
(x^2+2x-2x-4) (x^2+2) + 4
Simplificamos las 2x
(x^2-4) (x^2+2) + 4
Multiplicamos(x^2-4) (x^2+2)
x^4+2x^2-4x^2-8+4
Simplificamos y sumamos.
Rpta: x^4-2x^2-4
Saludos.